"Identification of the Neural Circuitry of Persistent Negative Symptoms in First Episode Schizophrenia"
Our work aims to identify how the brains of patients early in their first episode of schizophrenia with severe "negative symptoms" are different from the brains of patients with schizophrenia who do not have this same clinical picture and from the brains of healthy people without schizophrenia. We plan to use cutting-edge brain imaging approaches to understand these differences. One approach measures the thickness of parts of our brain, which can serve to tell us approximately how much brain tissue an individual might have in any given brain regions. The second approach tells us about the quality of the tissue that connects different brain regions, allowing these regions to communicate with each other.